Small-conductance, Ca -activated K channel 2 is the key functional component of SK channels in mouse urinary bladder
نویسندگان
چکیده
K. S. Thorneloe, A. M. Knorn, P. E. Doetsch, E. S. R. Lashinger, A. X. Liu, C. T. Bond, J. P. Adelman, and M. T. Nelson Department of Pharmacology, University of Vermont, Burlington, Vermont; Urogenital Biology, Cardiovascular and Urogenital Center of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania; and Vollum Institute, Oregon Health and Science University, Portland, Oregon
منابع مشابه
Small-conductance, Ca(2+) -activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder.
Small-conductance Ca(2+)-activated K(+) (SK) channels play an important role in regulating the frequency and in shaping urinary bladder smooth muscle (UBSM) action potentials, thereby modulating contractility. Here we investigated a role for the SK2 member of the SK family (SK1-3) utilizing: 1) mice expressing beta-galactosidase (beta-gal) under the direction of the SK2 promoter (SK2 beta-gal m...
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Rationale: Ca 2؉-activated K ؉ channels are present in a wide variety of cells. We have previously reported the presence of small conductance Ca 2؉-activated K ؉ (SK or K Ca) channels in human and mouse cardiac myocytes that contribute functionally toward the shape and duration of cardiac action potentials. Three isoforms of SK channel subunits (SK1, SK2, and SK3) are found to be expressed. Mor...
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